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. 2019 May 17;15(2):213–221. doi: 10.1007/s11302-019-09657-2

Fig. 4.

Fig. 4

THDCA weakly inhibits P2X2/P2X3 heteromers, while TLCA strongly potentiates human P2X2. a Left, representative current traces of Xenopus laevis oocytes expressing P2X2/P2X3, activated by of α,β-meATP (1 μM, black bar). Blue bars indicate the addition of THDCA or TLCA (20 μM); gray bar indicates control (solution exchange only). Right, mean currents in the presence of the indicated bile acids relative to the ATP-activated current prior to substance application, **p < 0.001; n = 10–11. b Left, representative current traces of Xenopus laevis oocytes expressing human P2X2, activated by ATP (1 μM, black bar). Colored bars indicate the addition of THDCA or TLCA (20 μM). Right, mean currents in the presence of the indicated bile acids relative to the ATP-activated current prior to substance application, ***p < 0.001; n = 7–8. Error bars represent standard error of the mean (S.E.M.)