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. 2019 May 17;15(2):213–221. doi: 10.1007/s11302-019-09657-2

Fig. 5.

Fig. 5

THDCA decreases the ATP affinity of rP2X2 and inhibits P2X2 currents in a concentration-dependent manner. a Left, representative current trace showing the application of increasing ATP concentrations and intermitted co-application of 20 μM THDCA to rP2X2 expressed in Xenopus laevis oocytes. Right, concentration-response curve for ATP in the absence or presence of 20 μM THDCA normalized to the application of 1 mM ATP alone, n = 12. b Left, representative current trace showing the activation of rP2X2 by ATP (10 μM) and the inhibitory effect of increasing concentrations of THDCA (white-blue bar). Right, concentration-response curve of THDCA in the presence of 10 μM ATP normalized to the current in absence of THDCA, n = 10. Error bars represent S.E.M.