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. 2019 Jul 10;10:1580. doi: 10.3389/fimmu.2019.01580

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Copyright © 2019 Melo, O'Brien, Phelan, Kennedy, Wood, Veerapen, Besra, Clarke, Foley, Ravi, MacCarthy, O'Toole, Ravi, Reynolds, Conroy, Hogan, O'Sullivan and Dunne.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MAIT cells are more abundant in node-negative OAC tumors. (A) MAIT cell frequency was assessed in n = 40 OAC tumors with respect to nodal status, and node-negative patients displayed higher MAIT cells (n = 16, p < 0.029) compared to node positive patients (n = 24), as assessed by Mann-Whitney U-test. (B) MAIT cell levels in blood did not show differences when node-negative (n = 32) and node-positive (n = 33) patients were compared. MAIT cell percentages in were also not different in tumors (C) (n = 24) or blood (D) (n = 43) of donors with different TRG scores, as assessed by (Kruskal-Wallis test followed by Dunn's Multiple Comparison Test). Horizontal bars indicate median values. *p < 0.05.