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. 2019 Jul 10;10:641. doi: 10.3389/fgene.2019.00641

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Copyright © 2019 O’Connell, McGregor, Emsley, Seedat and Warnich

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A flow diagram outlining the approach used in this study. (A) The first arm of the study involves identifying differentially expressed genes between healthy controls and schizophrenia patients, further divided into drug-naïve first-episode patients and chronic patients. (B) Differentially expressed genes were then used as candidates for genetic association with antipsychotic treatment response in a drug-naïve FES cohort. FES, first episode schizophrenia; CHR, chronic schizophrenia; SCZ, schizophrenia; CON, healthy control; eQTLs, expression quantitative trait loci.