Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 10;6:153. doi: 10.3389/fmed.2019.00153

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Lian, Matthaeus, Kaßmann, Daumke and Gollasch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic model on the role of caveolae in Ca²⁺ signaling in vascular smooth muscle. L-type Ca_v1.2 channels in noncaveolar membrane sites and T-type Ca_v3.2 channels in caveolae produce Ca²⁺ influx into vascular SMCs to release Ca²⁺ sparks via ryanodine type 2 receptors (RyR) in the sarcoplasmic reticulum (SR). The Ca²⁺ sparks produce a negative-feedback effect on vasoconstriction by activating maxi Ca²⁺-activated K⁺ (BK_Ca) channels.