Figure 2.

Causal effect estimates and 95% confidence intervals for lower birth weight on 21 diseases using the random-effects inverse variance weighted (IVW) method. Diseases are ordered based on their causal effect estimates. Estimations are carried out using both index SNPs and proxy SNPs. The dot size is proportional to the number of instrumental variables used for the given disease while dot color represents significance (p < 0.05 are highlighted in red). Disease names (x-axis) are further highlighted in red if the causal effects are significant after Bonferroni correction (p < 0.05/21).