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. 2019 Jul 10;10:618. doi: 10.3389/fgene.2019.00618

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Copyright © 2019 Zeng and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Causal effect estimates and 95% confidence intervals for lower birth weight on (A) CAD, (B) MI, (C) T2D, and (D) T2D_BMI. Estimations are carried out either using all SNPs (first column on x-axis) or using individual SNPs (the remaining columns on x-axis) based on Equation (14) in Text S3. Dot size is proportional to the effect size estimates, while dot color represents significance (p < 0.05 are highlighted in red). SNP that yields the largest causal effect estimate is also highlighted in red (x-axis).