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. 2019 Jul 16;9:10298. doi: 10.1038/s41598-019-46553-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of spiral ganglion neuron central projections following loss of Fzd3. (A) Reconstruction of ten approximately equally spaced afferents in Fig. 4E. (B) Reconstruction of ten approximately equally spaced afferents in 4F. (C,D) Selected individual axon tracings from a Fzd3^+/− control mouse (C) and a Fzd3^−/− mutant mouse (D), both at E18.5, overlaid onto boxes representing the mean dorsoventral limit of all control axons (dark gray), plus or minus one standard deviation (1 SD, medium gray), and plus or minus two standard deviations (2 SD, light gray) to display the analysis. Grayscale circles indicate mean/SD level crossings. (E) Linear Sholl analysis of 20 axons each from Fzd3^+/− and Fzd3^−/− mice. Bars represent means and standard error of the means for the number of times axons crossed the mean, one standard deviation (1 SD), and two standard deviation (2 SD) boundaries in (C,D). (F) Mean number of times an axon crossed over another axon from an analysis of 20 axons each from Fzd3^+/− and Fzd3^−/− mice. Error bars represent standard error of the means. **p < 0.01.