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Hypothesis for guidance of inner ear afferents by Fzd3. We predict that the Fzd3 gradient expressed along the cochlear neurons is, in part, responsible for correct targeting to the proper dorsoventral target within the hindbrain. (A) In the absence of Fzd3, there is no gradient across cochlear neurons and thus dorsoventral targeting is disrupted. (B) Whether this gradient extends to the vestibular neurons remains to be explored.
