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. 2019 Jul 10;10:1596. doi: 10.3389/fmicb.2019.01596

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Copyright © 2019 Djokic, Akoolo, Primus, Schlachter, Kelly, Bhanot and Parveen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Babesia microti (Bm) infection caused pronounced splenomegaly affecting splenic architecture in C3H mice at day 21 p.i. (A,B) A significant but moderate increase in spleen size is observed in N40 infected mice (2) compared to naïve mice (1) while very pronounced splenomegaly is observed in Bm infected (3) mice (^∗∗∗p < 0.001, df = 3, F = NA) and co-infected (4) mice (^∗∗∗p < 0.001, df = 5, F = NA). (C,D) H&E stained spleen sections displayed normal architecture with a clear demarcation between the white and red pulp (arrows 1 and 3, respectively) and marginal zone (arrow 2), in uninfected (C), and N40-infected (D) mice. (E,F) Demarcation between red and white pulp was indistinguishable in spleens of co-infected (E), and B. microti infected (F) mice. Bar in microscopic images represents 100 μm.