Table 5. Distribution of genotypes with respect to various parameters in male and female of essential hypertensive patients before and after drug treatment.
| Drug Treatment | Genotypes | |||||||
|---|---|---|---|---|---|---|---|---|
| Male | P value | Female | P value | |||||
| GG | TG | TT | GG | TG | TT | |||
| Base line readings | ||||||||
| Number | 59 | 34 | 2 | 123 | 41 | 11 | ||
| SBP | 152.37±6.75 | 156.32±4.56 | 150±5.66 | 0.0087 | 152.44±12.26 | 150.39±10.36 | 152.64±12.56 | 0.6210 |
| DBP | 90.46±2.11 | 92.59±1.44 | 90±2.83 | <0.0001 | 92.41±2.95 | 91.22±2.1 | 92.09±2.81 | 0.0610 |
| FBP | 105.49±5.59 | 109.21±8.93 | 101.5±3.54 | 0.0296 | 108.26±8.09 | 105.24±7.58 | 107±10.64 | 0.1216 |
| Readings after one year | ||||||||
| Mono drug therapy | ||||||||
| BB | 6 | 4 | 1 | 17 | 2 | 2 | ||
| SBP | 133.33±5.68 | 135.25±3.95 | 132 | 0.5758 | 131±7.38 | 131.5±10.61 | 134.5±4.95 | 0.8238 |
| DBP | 86.17±2.93 | 87.75±3.86 | 86 | 0.4807 | 89.29±5.63 | 88.5±7.78 | 90.5±2.12 | 0.0935 |
| FBP | 106.33±5.57 | 110.75±7.46 | 110 | 0.3120 | 109.41±10.1 | 111.5±9.19 | 113.5±9.19 | 0.8413 |
| Diuretic | 7 | 3 | 1 | 15 | 4 | 2 | ||
| SBP | 129.86±6.36 | 125.33±5.86 | 121 | 0.3233 | 128.27±6.69 | 127.5±9.75 | 125.5±4.95 | 0.8628 |
| DBP | 85.71±5.22 | 85.33±4.16 | 82 | 0.9146 | 87.13±6.52 | 88.25±6.24 | 88.5±6.36 | 0.9431 |
| FBP | 109.29±9.6 | 128.33±10.41 | 141 | 0.0227 | 110.07±11.15 | 117.75±12.5 | 135.5±17.68 | 0.0292 |
| CCB | 9 | 6 | 24 | 5 | 1 | |||
| SBP | 127.33±6.12 | 131.17±6.37 | - | 0.2623 | 132.75±6.22 | 128.6±9.26 | 134 | 0.2223 |
| DBP | 87.11±4.81 | 86.17±4.45 | - | 0.7090 | 89.46±6.37 | 87.4±5.77 | 88 | 0.5106 |
| FBP | 103.44±5.59 | 101.83±6.79 | - | 0.9945 | 106.83±8.08 | 105.8±7.82 | 104 | 0.7964 |
| Combination drug therapy | ||||||||
| Diuretic + BB | 14 | 10 | 27 | 15 | 2 | |||
| SBP | 121.79±4.39 | 124.7±5.06 | - | 0.1470 | 123.74±4.93 | 124.47±7.76 | 126.5±7.78 | 0.7973 |
| DBP | 82.43±3.52 | 84.1±3.7 | - | 0.2739 | 81.93±2.70 | 82.33±4.29 | 82.5±3.54 | 0.9193 |
| FBP | 105.29±5.88 | 115.5±8.7 | - | 0.0023 | 106.48±10.6 | 117.53±14.86 | 126.5±16.26 | 0.0079 |
| BB + CCB | 9 | 5 | 22 | 10 | 2 | |||
| SBP | 123.67±4.42 | 121.6±5.5 | - | 0.4550 | 124.82±6.46 | 121.8±4.89 | 125±5.66 | 0.4178 |
| DBP | 83.22±4.24 | 83.2±4.32 | - | 0.9934 | 83.68±3.93 | 82.6±3.53 | 83.5±4.95 | 0.7643 |
| FBP | 99.67±6.32 | 101.6±6.43 | - | 0.5962 | 103.59±10.26 | 106.6±8.11 | 102.5±9.19 | 0.6896 |
| Diuretic + CCB | 14 | 6 | 18 | 5 | 2 | |||
| SBP | 119.86±5.19 | 121.67±4.03 | - | 0.4584 | 120.83±4.67 | 120.6±7.83 | 126.5±7.78 | 0.3903 |
| DBP | 80.43±3.23 | 82.17±3.43 | - | 0.2923 | 81.17±2.53 | 83.4±5.18 | 83.5±6.36 | 0.3496 |
| FBP | 100.86±4.93 | 98.17±4.02 | - | 0.2556 | 100.89±10.44 | 99.8±9.65 | 100.5±6.36 | 0.9775 |