Table 1.

Methodological quality of randomized controlled trials (RCTs) included in the meta-analysis*.

First author, publication year	Random sequence generation	Allocation concealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete outcome data	Selective reporting	Other sources of bias	Quality
Raskob et al. (2018)	+	+	−	+	+	+	+	Low risk of bias
Raskob et al. (2016)	+	+	+	+	+	+	+	Low risk of bias
Agnelli et al. (2015)	?	?	+	+	+	+	+	Moderate risk of bias
Schulman et al. (2015)	−	+	+	+	+	+	+	Low risk of bias
Prins et al. (2014)	+	−	−	+	+	+	+	High risk of bias
Young et al. (2017)	+	+	−	+	+	+	+	Low risk of bias

*Cochrane Risk of Bias Tool for randomized controlled trials is used to assess bias for RCTs.

Low risk is represented by “+”,

high risk is represented by “−”,

unclear risk/insufficient information is represented by “?”.