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. 2019 Jul 10;10:1595. doi: 10.3389/fmicb.2019.01595

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Copyright © 2019 Zhai, Zhang, Cao, Ni, Xin, Deng, Wu, Ren, Yin and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The therapeutic effect of intraperitoneal injection of cecropin A on survival rate, colon length, and colon epithelium mucosa recovery in DSS-treated mice. (A) the experimental design; (B) survival rates of mice; (C,D) colon length; (E) colon morphology; (F) the histological score. The survival rate was measured by using the Kaplan–Meier method and the body weight change, diarrhea score and DAI were analyzed by one-way ANOVA. The data are shown as mean ± SEM with, ^*P < 0.05, ^∗∗∗P < 0.001. Because the survival rate changed every day, except for the control group (n = 9), the number of mice was changed in the 5 mg/kg, 15 mg/kg cecropin A or 4% DSS groups.