Table 4.
Association between Prechemotherapy Plasma DHEAS and DHEA Levels with Onset of Cancer‐Related Cognitive Impairment during Chemotherapy
| Cognitive Measure | DHEAS Level | DHEA Level | ||
|---|---|---|---|---|
| OR (95% CI) | Adjusted OR (95% CI)a | OR (95% CI) | Adjusted OR (95% CI)a | |
| Self‐perceived cognitive measure | ||||
| FACT‐Cog global score | 0.65 (0.36–1.19) | 0.48 (0.23–0.99) | 1.00 (0.96–1.03) | 1.00 (0.95–1.05) |
| Mental acuity | 0.55 (0.28–1.07) | 0.25 (0.08–0.74) | 0.99 (0.95–1.03) | 0.99 (0.94–1.06) |
| Concentration | 0.58 (0.29–1.15) | 0.45 (0.20–1.00) | 0.99 (0.96–1.04) | 1.00 (0.95–1.06) |
| Memory | 0.56 (0.24–1.28) | 0.64 (0.24–1.67) | 1.01 (0.97–1.06) | 1.02 (0.95–1.09) |
| Verbal fluency | 0.29 (0.09–0.88) | 0.27 (0.08–0.96) | 0.98 (0.92–1.04) | 0.97 (0.89–1.05) |
| Functional interference | 0.59 (0.26–1.35) | 0.55 (0.20–1.50) | 1.00 (0.96–1.06) | 1.04 (0.97–1.10) |
| Multitasking | 0.94 (0.54–1.63) | 0.89 (0.45–1.76) | 0.99 (0.96–1.03) | 0.98 (0.93–1.04) |
| Objective cognitive measure | ||||
| Processing speed | 0.36 (0.09–1.42) | 0.15 (0.01–1.78) | 0.96 (0.87–1.06) | 0.90 (0.73–1.11) |
| Response speed | 0.60 (0.17–2.17) | 0.09 (0.004–2.04) | 1.02 (0.96–1.08) | 1.10 (0.96–1.28) |
| Memory | 0.94 (0.50–1.77) | 1.00 (0.49–2.06) | 1.02 (0.97–1.06) | 1.01 (0.96–1.06) |
| Attention | 1.33 (0.64–2.76) | 1.53 (0.53–4.43) | 1.00 (0.96–1.06) | 1.03 (0.97–1.10) |
Bolded values indicate statistical significance.
CI = confidence interval; DHEA = dehydroepiandrosterone; DHEAS = DHEA sulfate; FACT‐Cog = Functional Assessment of Cancer Therapy–Cognitive Function; OR = odds ratio.
a
Adjusted for age, years of education, fatigue level, anxiety level, insomnia, type of chemotherapy regimen, and menopausal status.