Table 3.

Association between Imaging Features and ILA Progression

	Unadjusted Analysis		Adjusted Analysis*
	OR (95% CI)	P Value	OR (95% CI)	P Value
Centrilobular nodules	0.2 (0.1–0.4)	<0.0001	0.2 (0.1–0.5)	0.0002
Ground glass†	—	—	—	—
Subpleural reticular markings	5.9 (2.3–15)	0.0002	6.6 (2.3–19)	0.0004
Nonemphysematous cysts	3.1 (1.6–5.9)	0.0005	2.5 (1.3–5.1)	0.009
Lower lobe predominant changes	5.2 (1.8–15)	0.002	6.7 (1.8–25)	0.004
Traction bronchiectasis	5.9 (2.3–14.9)	0.0002	6.6 (2.3–19)	0.0004
Honeycombing‡	—	—	—	—

For definition of abbreviations, see Table 2.

^*Adjusted for age, sex, body mass index, pack-years smoking, current smoking status, and MUC5B genotype.

^†Odds of progression cannot be calculated for ground glass because all participants with ILA had ground glass on computed tomography scan.

^‡Odds of progression cannot be calculated because all participants with honeycombing had evidence of imaging progression.