TABLE 4.
Prevalence of Abnormal Biochemical Parameters in Adult and Pediatric IBD
| All Children, No. (%) | All Adults, No. (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | CD | UC | IBDU | UC+IBDU | Total | CD | UC | IBDU | UC+IBDU | |
| (n = 203) | (n = 179) | (n = 4) | (n = 20) | (n = 24) | (n = 387) | (n = 274) | (n = 97) | (n = 16) | (n = 113) | |
| Albumin | 57 (28.1) | 55 (30.7) | 0 (0) | 2 (10.0) | 2 (8.3)e | 91 (23.5) | 80 (29.2) | 10 (10.3)g | 1 (6.2)e | 11 (9.7)g |
| Hemoglobin | 120 (59.1) | 109 (60.9) | 3 (75.0) | 8 (40.0) | 11 (45.8) | 143 (37.0)c | 122 (44.5)b | 18 (18.6)a,i | 3 (18.8) | 21 (18.6)a,g |
| Iron | 77 (37.9) | 72 (40.2) | 0 (0) | 5 (25.0) | 5 (20.8) | 98 (25.3)a | 85 (31.0) | 13 (13.4)f | 0 (0) | 13 (11.5)g |
| B12 | 11 (5.4) | 10 (5.6) | 0 (0) | 1 (5.0) | 1 (4.2) | 75 (19.4)c | 72 (26.3)c | 3 (3.1)g | 0 (0)e | 3 (2.7)g |
| Folate | 6 (3.0) | 6 (3.4) | 0 (0) | 0 (0) | 0 (0) | 10 (2.6) | 9 (3.3) | 1 (1.0) | 0 (0) | 1 (0.9) |
| CRP | 101 (49.8) | 99 (55.3) | 0 (0) | 2 (10.0)f | 2 (8.3)g | 149 (38.5)a | 130 (47.4) | 15 (15.5)g | 4 (25.0) | 19 (16.8)g |
| Male Children, No. (%) | Male Adults, No. (%) | |||||||||
| Total | CD | UC | IBDU | UC+IBDU | Total | CD | UC | IBDU | UC+IBDU | |
| (n = 114) | (n = 105) | (n = 0) | (n = 9) | (n = 9) | (n = 195) | (n = 141) | (n = 51) | (n = 3) | (n = 54) | |
| Albumin | 32 (28.1) | 32 (30.5) | 0 (0) | 0 (0) | 0 (0) | 41 (21.0) | 39 (27.7) | 2 (3.9)f | 0 (0) | 2 (3.7)g |
| Hemoglobin | 68 (59.7) | 65 (61.9) | 0 (0) | 3 (33.3) | 3 (33.3) | 78 (40.0)b | 66 (46.8)a | 11 (21.6)e | 1 (33.3) | 12 (22.2)e |
| Iron | 43 (37.7) | 41 (39.1) | 0 (0) | 2 (22.2) | 2 (22.2) | 48 (24.6)a | 41 (29.1) | 7 (13.7)e | 0 (0) | 7 (13.0)e |
| B12 | 6 (5.3) | 6 (5.7) | 0 (0) | 0 (0) | 0 (0) | 32 (16.4)a | 29 (20.57)b | 3 (5.9)e | 0 (0) | 3 (5.6)e |
| Folate | 5 (4.4) | 5 (4.8) | 0 (0) | 0 (0) | 0 (0) | 5 (2.6) | 5 (3.6) | 0 (0) | 0 (0) | 0 (0) |
| CRP | 59 (51.8) | 58 (55.2) | 0 (0) | 1 (11.1)e | 1 (11.1)e | 74 (38.0)a | 66 (46.8) | 6 (11.8)g | 2 (66.7) | 8 (14.8)f |
| Female Children, No. (%) | Female Adults, No. (%) | |||||||||
| Total | CD | UC | IBDU | UC+IBDU | Total | CD | UC | IBDU | UC+IBDU | |
| (n = 89) | (n = 74) | (n = 4) | (n = 11) | (n = 15) | (n = 192) | (n = 133) | (n = 46) | (n = 13) | (n = 59) | |
| Albumin | 25 (28.1) | 23 (31.1) | 0 (0) | 2 (18.2) | 2 (13.3) | 50 (26.0) | 41 (30.8) | 8 (17.4)d | 1 (7.7) | 9 (15.3)e |
| Hemoglobin | 52 (58.4) | 44 (59.5) | 3 (75.0) | 5 (45.5) | 8 (53.3) | 65 (33.9)c | 56 (42.1)a | 7 (15.2)e | 2 (15.4) | 9 (15.3)a,f |
| Iron | 34 (38.2) | 31 (41.9) | 0 (0) | 3 (27.3) | 3 (20.0) | 50 (26.0)a | 44 (33.1) | 6 (13.0)e | 0 (0) | 6 (10.2)f |
| B12 | 5 (5.6) | 4 (5.4) | 0 (0) | 1 (9.1) | 1 (6.7) | 43 (22.4)b | 43 (32.3)c,d | 0 (0)g | 0 (0)e | 0 (0)g |
| Folate | 1 (1.1) | 1 (1.4) | 0 (0) | 0 (0) | 0 (0) | 5 (2.6) | 4 (3.01) | 1 (2.2) | 0 (0) | 1 (1.7) |
| CRP | 42 (47.2) | 41 (55.4) | 0 (0) | 1 (9.1)e | 1 (6.7)f | 75 (39.1) | 64 (48.1) | 9 (19.6)e | 2 (15.4) | 11 (18.6)f |
Prevalence of abnormal biochemical markers in our IBD cohort. The numbers of patients with low albumin, hemoglobin, iron, vitamin B12, and folate, and with high CRP levels, are shown.
a P < 0.05, bP < 0.001, cP < 0.0001 vs children.
d P < 0.05 vs male.
e P < 0.05, fP < 0.0002, gP < 0.0001 vs CD.