Table 1.
Correlation between DNMT3a expression and clinicopathological characteristics in 118 cases of PDAC
| Characteristics | All cases (N=118) | DNMT3a expression | χ2 value | P-value | |
|---|---|---|---|---|---|
| Low (%) | High (%) | ||||
| Age (years) | |||||
| ＜60 | 56 | 33 (28.0) | 23(19.5) | ||
| ≥60 | 62 | 38 (32.2) | 24(20.3) | 0.068 | 0.794 |
| Gender | |||||
| Female | 52 | 38 (32.2) | 14(11.9) | ||
| Male | 66 | 33 (28.0) | 33(28.0) | 6.463 | 0.011 |
| Tumor size(cm) | |||||
| ＜4 | 51 | 35(29.7) | 16(13.6) | ||
| ≥4 | 67 | 36(30.5) | 31(26.3) | 2.681 | 0.102 |
| TNM stage | |||||
| I | 48 | 35 (29.7) | 13(11.0) | ||
| Ⅱ+Ⅲ | 70 | 36 (30.5) | 34(28.8) | 5.486 | 0.019 |
| Differentiation | |||||
| Moderate-well | 100 | 65(55.1) | 35(29.7) | ||
| Poor | 18 | 6(5.1) | 12(10.2) | 6.383 | 0.012 |
| Vascular invasion | |||||
| No | 62 | 42(35.6) | 20(16.9) | ||
| Yes | 56 | 29(24.6) | 27(22.9) | 3.126 | 0.077 |
| Perineural invasion | |||||
| No | 95 | 56(47.5) | 39(33.1) | ||
| Yes | 23 | 15(12.7) | 8(6.8) | 0.304 | 0.582 |
| Ki67 | |||||
| ≤20 | 86 | 60 (50.8) | 26(22.0) | ||
| ＞20 | 32 | 11(9.3) | 21(17.8) | 12.19 | 0.001 |
Abbreviations: DNMT, DNA methyltransferase; PDAC, pancreatic ductal adenocarcinoma.