Table 2.

Univariate survival analysis (Log-Rank) of the clinicopathological characteristics, DNMT3a and Ki67 in 118 cases of PDAC

Variable	Cases	Events	Median survival (months)	P-value
Age				0.314
≤60	56	48	14.66
＞60	62	49	17.69
Sex				0.620
Female	52	41	17.23
Male	66	56	16.24
Tumor size				0.017
＜4 cm	51	39	23.97
≥4 cm	67	58	14.66
Lymph node metastasis				0.027
No	81	64	19.56
Yes	37	33	11.31
TNM staging				0.037
I	48	38	23.90
II + III	70	59	13.38
Tumor differentiation				0.035
Well-moderate	100	82	18.84
Poor	18	15	7.83
Vascular invasion				0.052
No	62	49	21.60
Yes	56	48	14.66
Perineural invasion				0.595
No	95	77	16.90
Yes	23	20	16.41
Serum CA199a				0.007
≤35 U/mL	16	9	28.73
＞35 U/mL	85	74	15.03
Ki67				0.009
Low	86	68	19.17
High	32	29	12.43
DNMT3a expression				0.009
Low	71	56	21.60
High	47	41	12.49

Note: ^aOnly 101 patients had preoperative CA199 level data in this study.

Abbreviations: DNMT, DNA methyltransferase; PDAC, pancreatic ductal adenocarcinoma.