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. 2019 Jul 12;10:217–226. doi: 10.2147/JBM.S206459

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© 2019 Kibata et al.

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Clinical concentrations of lenalidomide (LEN) sustained IFN-α production by peripheral blood mononuclear cells (PBMCs). Human PBMCs were incubated for 24 h with the indicated concentrations of LEN or vehicle in the presence of 3 μM CpG-ODN 2216. After 24 h, the concentrations of IFN-α in the culture supernatants were measured by ELISA. Data are shown as means ± SEMs of seven independent donors. The data were normalized to the value obtained for the vehicle control. The mean (range) of absolute concentrations of CpG-ODN 2216 + vehicle control was 6396 pg/mL (1006–12,938 pg/mL). Statistical significance was determined using paired Student’s t-tests; p-values were calculated for each concentration of LEN versus vehicle control.