TABLE 7.
Analysis of Variance Comparing IBDSI-LF Scores for those With Active or Inactive Symptoms for the Full IBD Sample and Within Each Disease Type
| Measure | Level of Active Disease | Total IBD | F, comparing disease activity levels within each measure | CD | UC |
|---|---|---|---|---|---|
| N ≤ 264 | n ≤ 140 | n ≤ 122 | |||
| Mean (SD) | Mean (SD) | Mean (SD) | |||
| 95% CI | 95% CI | 95% CI | |||
| Harvey-Bradshaw Index for CD | Active symptoms (≥5) | — | 126.63 | 37.3 (15.8) | — |
| P < 0.001 | 32.5–42.2 | ||||
| Inactive (<5) | — | 12.4 (9.1) | — | ||
| 10.5–14.5 | |||||
| Powell-Tuck Index for UC | Active symptoms (≥5) | — | 115.14 | — | 34.6 (18.0) |
| P < 0.001 | 28.4–40.8 | ||||
| Inactive (<5) | — | — | 9.4 (7.8) | ||
| 7.8–11.1 | |||||
| Gastroentero-logist Global Assessment | Severely active | 62.0 (22.7) | 82.99 | 83.0 a | 57.8 (22.6) |
| 38.2–85.8 | P < 0.001 | 29.7–85.9 | |||
| Moderately active | 38.5 (15.7) | 41.7 (13.1) | 33.6 (18.4) | ||
| 33.3–43.7 | 36.0–47.4 | 23.4–43.8 | |||
| Mildly active | 26.2 (13.9) | 24.4 (11.4) | 29.0 (17.0) | ||
| 22.6–29.9 | 20.5–28.3 | 21.7–36.4 | |||
| Inactive (in remission) | 11.1 (10.1) | 13.6 (11.9) | 8.6 (7.0) | ||
| 9.5–12.7 | 10.9–16.3 | 7.0–10.2 | |||
| Gastroentero-logist Rating of Disease Status | Flaring currently (symptoms worse than usual) | 35.4 (19.4) | 109.57 | 36.1 (16.7) | 34.5 (22.6) |
| 30.5–40.2 | P < 0.001 | 30.4–41.7 | 25.9–43.1 | ||
| Not flaring currently | 13.3 (12.1) | 15.5 (13.0) | 11.0 (10.6) | ||
| 11.5–15.1 | 12.7–18.2 | 8.7–13.3 | |||
| Manitoba Inflammatory Bowel Disease Index | (1) Constantly active (symptoms every day) | 41.2 (23.2) | 43.24 | 39.2 (21.9) | 43.0 (24.9) |
| 32.7–49.7 | P < 0.001 | 27.1–51.3 | 29.7–56.3 | ||
| (2) Often active (symptoms most days) | 31.4 (14.1) | 34.7 (13.8) | 26.8 (13.5) | ||
| 26.8–35.2 | 29.1–40.2 | 20.3–33.3 | |||
| (3) Sometimes active (symptoms on some days, for instance 1–2 days/week) | 22.0 (13.8) | 23.6 (13.7) | 20.2 (14.1) | ||
| 17.7–26.4 | 17.6–29.7 | 13.3–27.0 | |||
| (4) Occasionally active (symptoms 1–2 days/month) | 17.1 (10.2) | 17.6 (10.4) | 16.0 (10.2) | ||
| 13.5–20.8 | 13.0–22.2 | 8.7–23.3 | |||
| (5) Rarely active (symptoms only a few days of the past 3 months) | 13.4 (10.0) | 14.4 (10.5) | 11.9 (9.4) | ||
| 10.4–16.9 | 9.9–18.9 | 6.7–17.1 | |||
| (6) I was well in the past 3 months (what I consider a remission or absence of symptoms) | 6.2 (5.5) | 7.6 (5.6) | 5.2 (5.3) | ||
| 4.9–7.5 | 5.5–9.7 | 3.5–6.8 | |||
| ≤3 | 30.6 (18.4) | 124.30 | 31.8 (17.1) | 29.3 (19.9) | |
| 27.2–34.0 | P < 0.001 | 27.4–36.1 | 23.8–34.7 | ||
| >3 | 10.8 (9.6) | 13.0 (10.2) | 8.3 (8.3) | ||
| 9.2–12.4 | 10.7–15.3 | 6.3–10.3 |
an = 1.