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Salivary gland tropism of AAVs 2, 8, and 5 when administered directly to the submandibular salivary gland. Transduction of WT murine salivary glands (A, B, C) represented by GFP expression 1 month after AAV2 (A), AAV8 (B), or AAV5 (C) administration. Off-target liver expression (D, E, F) was observed for AAV2 (D), AAV8 (E), and AAV5 (F) vectors, with AAV8 being the most liver tropic. Scale bar (bottom left corner F) is 50 μm.
