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Ablation of off-target AAV5 liver tropism achieved by inclusion of miR122 and miR206 target sites into vector construct. Transduction of WT murine salivary glands (A), represented by GFP expression, is unaffected by the inclusion of miR122/miR206 TS in the vector. However, off-target GFP expression in the liver (B) is completely abolished. Transduction was measured 1 month after vector administration and the scale bar (bottom left B) is 100 μm.
