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. 2019 Jul 17;16:31. doi: 10.1186/s12014-019-9251-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — ROC and survival analysis. a ROC curves for PZ, SHBG, VWF and CA19-9 as single biomarker, as well as the best-performing composite biomarker in stages III & IV, III, and IV PDAC patients. b For all the patients included, the survival curves of PDAC patients stratified by predictive composite biomarker for stages III & IV, III, and IV PDAC patients. c After exclusion of one stage IV patient who was Good-responder, but had exceptional high VWF and CA 19-9 concentrations, the survival curves of PDAC patients were significantly improved