Table 2.

The summary of ROC analysis of PZ, SHBG, VWF and CA19-9

Marker	Stages III and IV			Stage III			Stage IV
	AUC	Sensitivity at 90% specificity	Specificity at 90% sensitivity	AUC	Sensitivity at 90% specificity	Specificity at 90% sensitivity	AUC	Sensitivity at 90% specificity	Specificity at 90% sensitivity
PZ	0.60	0.22	0.06	0.68	0	0.50	0.46	0	0.10
SHBG	0.60	0.27	0	0.57	0.27	0	0.69	0.33	0.28
VWF	0.59	0.08	0.04	0.72	0.09	0.38	0.49	0.20	0.17
CA19-9	0.65	0.23	0.38	0.58	0.18	0.50	0.65	0.20	0.44
PZ + CA19-9	0.66	0.22	0.33	0.73	0	0.625	0.70	0	0.40
SHBG + CA19-9	0.62	0.12	0.38	0.72	0.45	0.25	0.78	0.33	0.22
VWF + CA19-9	0.67	0.19	0.38	0.73	0.09	0.5	0.69	0.20	0.50
PZ + SHBG	0.60	0.17	0.22	0.70	0.18	0.5	0.79	0.43	0.30
PZ + VWF	0.64	0.11	0.22	0.72	0	0.50	0.46	0	0.10
SHBG + VWF	0.58	0.08	0.04	0.80	0.36	0.38	0.72	0.47	0.33
PZ + SHBG + CA19-9	0.64	0.17	0.33	0.78	0.27	0.50	0.87	0.86	0.40
PZ + VWF + CA19-9	0.73	0.11	0.39	0.77	0	0.75	0.70	0.29	0.40
SHBG + VWF + CA19-9	0.68	0.23	0.38	0.83	0.36	0.50	0.77	0.47	0.22
PZ + SHBG + VWF	0.65	0.17	0.33	0.75	0.18	0.50	0.80	0.86	0.40
PZ + SHBG + VWF + CA19-9	0.71	0.11	0.39	0.83	0.27	0.63	0.87	0.71	0.30

These proteins were tested as single or composite biomarker for predicting Good-responders from Limited-responders with or without inclusion of CA 19-9. PZ is a vitamin K-dependent glycoprotein, which regulates blood coagulation. SHBG is a glycoprotein that binds hormones, which is an index of testosterone level and an inflammatory marker. VWF is a blood glycoprotein maintaining hemostasis, which also acts in inflammation and antitumor