Table 1.
Characteristics of the Patients at Baseline According Age and AMH Level
| Characteristic | Age<35 yrs | Age ≥ 35 yrs | ||||
|---|---|---|---|---|---|---|
| young low-AMH (N = 1819) |
young average-AMH (N = 3642) |
young high-AMH (N = 1822) |
older low-AMH (N = 537) |
older average-AMH (N = 1074) |
older high-AMH (N = 537) |
|
| AMH range[%(ng/ml)] |
0-25th quartile (0.01–1.32) |
25th–75th quartile (1.32–3.99) |
75th–100th quartile (3.99–22.05) |
0-25th quartile (< 0.01–0.62) |
25th–75th quartile (0.63–2.41) |
75th–100th quartile (2.41–22.05) |
| Age (yrs) | 29.46 ± 3.18 | 28.74 ± 3.16 | 28.26 ± 3.10 | 38.67 ± 2.90 | 37.88 ± 2.57 | 37.12 ± 2.16 |
| BMI (kg/m2) | 23.12 ± 3.69 | 22.90 ± 3.42 | 22.82 ± 3.62 | 24.00 ± 3.15 | 24.11 ± 3.19 | 23.99 ± 3.29 |
| AFC | 10.52 ± 4.78a,b | 14.46 ± 5.80c | 19.78 ± 9.41 | 7.14 ± 2.93d,e | 10.47 ± 5.38f | 15.18 ± 7.04 |
| Fertility history | ||||||
| Previous conception[%(n/N)] | 41.67(758/1819)g | 39.07(1423/3642) | 34.69(632/1822) | 72.75(388/537) | 74.77(803/1074) | 66.85(359/537) |
| Concomitant infertility factors | ||||||
| Tubal factors[%(n/N)] | 66.08(1202/1819)b | 64.74(2358/3642)c | 60.21(1097/1822) | 68.34(367/537) | 71.79(771/1074) | 70.58(379/537) |
| Ovulatory dysfunction[%(n/N)] | ||||||
| PCOS[%(n/N)] | 2.25(41/1819)a,b | 7.36(268/3642)c | 23.49(428/1822) | 0.56(3/537)e | 1.96(21/1074)f | 10.80(58/537) |
| POI[%(n/N)] | 5.22(95/1819)a,b | 0.41(15/3642) | 0(0/0) | 8.39(45/537)d,e | 1.96(21/1074) | 0.19(1/537) |
| Male factors[%(n/N)] | 30.90(562/1819)a,b | 36.55(1331/3642) | 37.87(690/1822) | 22.91(123/537) | 26.44(284/1074) | 25.14(135/537) |
| Controlled Ovarian Hyperstimulation outcome | ||||||
| Gonadotropin start dose (IU) | 196.40 ± 48.96a,b | 177.05 ± 44.02c | 162.95 ± 42.41 | 230.48 ± 49.82d,e | 218.14 ± 48.73f | 197.69 ± 41.29 |
| Total Gonadotropin dose (IU) | 2130.27 ± 982.84g | 1937.00 ± 778.37 | 1782.24 ± 762.80 | 2375.30 ± 1108.22 | 2286.36 ± 970.59 | 2140.51 ± 800.74 |
| No. of days of ovarian stimulation | 10.52 ± 2.02g | 10.82 ± 1.78 | 10.94 ± 1.95 | 10.06 ± 2.28 | 10.41 ± 2.03 | 10.85 ± 1.93 |
| Endometrial thickness on hCG trigger day(cm) | 1.11 ± 0.20 | 1.13 ± 0.18 | 1.12 ± 0.18 | 1.02 ± 0.23d,e | 1.07 ± 0.20 | 1.10 ± 0.20 |
AMH anti-Müllerian hormone, BMI body Mass Index, AFC antral follicle count
Continuous data was presented as mean ± standard deviation, and categorical variable was presented as percentile (number)
Significant subgroup differences (Bonferroni pairwise comparison, p < 0.05/3) are indicated by superscripts “a: low AMH vs. average AMH in women < 35 yrs”, “b: low AMH vs. high AMH in women < 35 yrs”, “c: average AMH vs. high AMH in women < 35 yrs”, “d: low AMH vs. average AMH in women ≥35 yrs”, “e significant difference for low AMH vs. high AMH in women ≥35 yrs”,“f significant difference for average AMH vs. high AMH in women ≥35 yrs” g: p < 0.05 was considered statistically significant difference for main effect