Table 2.
Outcomes of Pregnancy
| Characteristic | Age<35 yrs | Age ≥ 35 yrs | ||||
|---|---|---|---|---|---|---|
| young low-AMH | young average-AMH | young high-AMH | older low-AMH | older average-AMH | older high-AMH | |
| (N = 1819) | (N = 3642) | (N = 1822) | (N = 537) | (N = 1074) | (N = 537) | |
| No. of oocytes retrieved(n) | 9.15 ± 5.09a,b | 13.13 ± 5.49c | 16.04 ± 6.44 | 4.53 ± 3.25d,e | 8.45 ± 4.39f | 12.91 ± 5.73 |
| No. of 2PN(n) | 5.32 ± 3.59a,b | 7.88 ± 4.21c | 9.31 ± 4.59 | 2.70 ± 2.30d,e | 5.15 ± 3.53f | 7.79 ± 4.39 |
| No. of GQE (cleavage stage) (n) | 2.42 ± 2.53a,b | 3.50 ± 3.22 | 4.08 ± 3.78 | 1.31 ± 1.54d,e | 2.28 ± 2.36f | 3.60 ± 3.32 |
| IVF(n) | 1180 | 2129 | 1158 | 405 | 722 | 370 |
| ICSI(n) | 447 | 1036 | 501 | 117 | 218 | 109 |
| Fresh embryo transfer(n) | 1510 | 2923 | 1138 | 396 | 905 | 426 |
| Frozen embryo transfer(n) | 722 | 2069 | 1443 | 135 | 475 | 383 |
| CPR[%(n/N)] | 58.01(1295/2232)a,b | 62.90(3140/4992)c | 66.33(1712/2581) | 33.90(180/531)d,e | 41.45(572/1380)f | 49.44(400/809) |
| CCPR[%(n/N)] | 65.37(1189/1819)a,b | 78.31(2852/3642)c | 83.15(1515/1822) | 30.73(165/537)d,e | 49.07(527/1074)f | 66.11(355/537) |
| LBR [%(n/N)] | 48.52(1083/2232)a,b | 54.65(2728/4992) | 56.68 (1463/2581) | 20.34(108/531)d,e | 32.46(448/1380) | 37.45(303/809) |
| CLBR[%(n/N)] | 56.35(1025/1819)a,b | 69.99(2549/3642) | 72.99(1330/1822) | 20.11(108/537)d,e | 39.29(422/1074)f | 52.89(284/537) |
| Miscarriage rate [%(n/N)] | 16.37(212/1295) | 13.28(417/3140) | 14.54(249/1712) | 35.56(64/180)d,e | 21.68(124/572) | 21.50(86/400) |
2PN 2 pronuclear, GQE good-quality embryo, CPR clinical pregnancy rate, CCPR cumulative clinical pregnancy rate, LBR live birth rate, CLBR cumulative live birth rate
Continuous data was presented as mean ± standard deviation, and categorical variable was presented as percentile (number)
Significant subgroup differences (Bonferroni pairwise comparison, p < 0.05/3) are indicated by superscripts “a: low AMH vs. average AMH in women < 35 yrs”, “b: low AMH vs. high AMH in women < 35 yrs”, “c: average AMH vs. high AMH in women < 35 yrs”, “d: low AMH vs. average AMH in women ≥35 yrs”, “e significant difference for low AMH vs. high AMH in women ≥35 yrs”,“f significant difference for average AMH vs. high AMH in women ≥35 yrs”