Table 7.
Comparison of performance between datasets (SEPSIS score ≥ 5)
| Estimate | Derivation cohort n = 16063 |
Validation cohort n = 6882 |
|---|---|---|
| Undifferentiated medical cases (estimate(95% confidence interval)) | ||
| Sensitivity | 0.39 (0.35–0.43) | 0.37 (0.31–0.44) |
| Specificity | 0.96 (0.96–0.96) | 0.96 (0.96–0.97) |
| Positive predictive value | 0.27 (0.24–0.30) | 0.27 (0.23–0.32) |
| Negative predictive value | 0.98 (0.97–0.98) | 0.98 (0.97–0.98) |
| Positive likelihood ratio | 9.48 (8.35–10.76) | 9.72 (7.96–11.87) |
| Negative likelihood ratio | 0.64 (0.60–0.68) | 0.65 (0.59–0.72) |
| Infection present (estimate(95% confidence interval)) | ||
| Sensitivity | 0.39 (0.35–0.43) | 0.37 (0.31–0.44) |
| Specificity | 0.99 (0.98–0.99) | 0.98 (0.98–0.99) |
| Positive predictive value | 0.50 (0.45–0.55) | 0.49 (0.42–0.56) |
| Negative predictive value | 0.98 (0.97–0.98) | 0.98 (0.97–0.98) |
| Positive likelihood ratio | 26.1 (22.2–30.1) | 24.8 (19.3–31.9) |
| Negative likelihood ratio | 0.62 (0.58–0.66) | 0.64 (0.58–0.70) |