Table 8.

Comparison of miRFA to other available tools for functional analysis of miRNAs

Feature		Tool
		miRFA	miRCancerdb	multiMiR	RBiomirGS	MiRComb	miRLab	miRpath	miEAA	TAM	GeneTrail2
Platform		R/Web-based	R/Web-based	R	R	R	R	Web-based	Web-based	Web-based	Web-based
MiRNA input/expression	Mature miRNA	✓		✓	✓	✓	a	✓	✓		✓
	Precursor miRNA		✓			✓	✓		✓	✓
MiRNA target prediction database	Experimentally validated database(s)	✓		✓	✓		✓	✓	✓		✓
	Target prediction database(s)	✓	✓	✓	✓	✓	✓	✓
Correlation analysis expression levels	mRNA expression	✓	✓			✓	✓
	Protein expression	✓	✓
	Negative correlation	✓	✓			✓	✓b
	Positive correlation	✓	✓
Functional enrichment		✓			✓	✓	✓	✓	✓	✓	✓
Disease-specific		✓	✓	✓			✓
miRNA annotation c									✓	✓	✓

^a Based on if the user implements built in TCGA retriever

^b Negative correlations are ranked at the top

^c Includes cluster, family, functions, diseases, tissue specificity