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. 2019 Jul 17;17:135. doi: 10.1186/s12916-019-1364-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a, b Manhattan plot (a) and Q–Q plot (b) of genome-wide markers for NAFLD in European ancestry (1106 cases and 8571 controls). A total of 1106 cases of NAFLD and 8571 controls were analyzed after quality control. Logistic regression analysis was performed for 7,261,527 variants with MAF > 1% assuming an additive genetic model, adjusted for age, sex, BMI, genotyping site, and genetic ancestry (principal components 1 through 3). Results are plotted as –log10 p values on the y-axis by position in chromosome (x-axis) (NCBI build 37)