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. 2019 Jul 17;17:135. doi: 10.1186/s12916-019-1364-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a–c LocusZoom plot of the associations signals in three previously known regions for NAFLD. a Confirmation at 22q13 for PNPLA3. SNP rs738409 is a missense variation (I148M) in PNPLA3 produced the best effect (p = 1.70 × 10^− 20). b Detected signal at 19p12 (GATAD2A, NCAN, TM6SF2) region. The best marker in this study was rs56408111 (p = 5.26 × 10^− 6). The linkage disequilibrium (LD) between rs56408111 and previously known SNP rs4808199 was r² = 0.24, D’ = 0.74. c Detected signal at 8q24 (TRIB1) genetic region. The best marker in this study (rs2980888) is shown (see also Additional file 1: Table S2). Estimated recombination rates (from HapMap) are plotted in cyan to reflect the local LD structure. The SNPs surrounding the most significant variant are color-coded to reflect their LD with the index SNP (taken from pairwise r2 values from the HapMap CEU database, www.hapmap.org). Regional plots were generated using LocusZoom (http://csg.sph.umich.edu/locuszoom)