Table 1.
CVD incidence and baseline characteristics of the entire study population
| CPRD female N = 1,965,078 | CPRD male N = 1,890,582 | |
|---|---|---|
| Outcome variables | ||
| Incident CVD cases | 86,547 | 107,051 |
| Person years | 13,801,919 | 12,977,235 |
| Rate per 1000 person-years | 6.27 | 8.24 |
| Demographics | ||
| Age | 43.07 (15.94) | 41.84 (14.57) |
| Ethnicity | ||
| Recorded | 42.07% | 38.21% |
| White/not recorded | 94.12% | 94.48% |
| Indian | 1.14% | 1.19% |
| Pakistani | 0.45% | 0.49% |
| Bangladeshi | 0.14% | 0.19% |
| Other Asian | 0.84% | 0.78% |
| Black | 1.73% | 1.52% |
| Chinese | 0.33% | 0.23% |
| Other | 1.27% | 1.12% |
| Test data | ||
| BMI | 25.60 (5.60) | 26.12 (4.54) |
| Cholesterol/HDL ratio | 3.72 (1.20) | 4.48 (1.40) |
| SBP | 123.91 (18.28) | 130.03 (16.48) |
| SBP variability | 9.47 (5.98) | 10.13 (6.80) |
| Smoking status | Never = 56.04%, Ex = 16.97%, Current = 26.99% | Never = 46.63%, Ex = 17.48%, Current = 35.99% |
| Medical history | ||
| Atrial fibrillation | 0.44% | 0.57% |
| Atypical antipsychotic medication use | 0.30% | 0.33% |
| Chronic kidney disease | ||
| Stage 3/4/5 | 0.45% | 0.32% |
| Stage 4/5 | 0.12% | 0.15% |
| Corticosteroid use | 0.48% | 0.30% |
| Erectile dysfunction | NA | 1.45% |
| Family history of CVD | 15.08% | 11.02% |
| HIV/AIDS | 0.06% | 0.09% |
| Migraine | 7.27% | 2.94% |
| Rheumatoid arthritis | 0.69% | 0.26% |
| Severe mental illness | 8.63% | 4.59% |
| Systemic lupus erythematosus | 0.10% | 0.01% |
| Treated hypertension | 6.18% | 4.50% |
| Type 1 diabetes | 0.21% | 0.28% |
| Type 2 diabetes | 1.16% | 1.42% |
| Variables not in QRISK | ||
| Number medical records in the previous year | 14.94 (13.97) | 8.83 (11.45) |
| > 50 medical records in the previous year | 2.84% | 1.37% |
| Number of prescription items in the previous year | 9.60 (19.87) | 5.72 (16.00) |
| Number with > 50 prescription items in the previous year | 3.49% | 2.04% |
| Alcohol abuse | 0.65% | 1.46% |
| Anxiety | 13.44% | 7.96% |
| Left ventricular hypertrophy | 0.14% | 0.18% |
| Region | ||
| North East | 1.89% | 1.96% |
| North west | 13.10% | 13.38% |
| Yorkshire and the Humber | 3.93% | 3.85% |
| East Midlands | 3.14% | 3.23% |
| West Midlands | 11.04% | 11.28% |
| East of England | 11.67% | 11.68% |
| South west | 11.99% | 11.88% |
| South Central | 12.84% | 12.81% |
| London | 17.52% | 17.18% |
| South East Coast | 12.88% | 12.74% |