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. 2019 Jul 17;39(29):5773–5793. doi: 10.1523/JNEUROSCI.0213-19.2019

Figure 2.

Figure 2.

Pharmacological manipulations of ASIC1a in ACC affect inflammatory pain hypersensitivity. A, Schematics of the experimental protocol for C. The animals were pretreated with the selective ASIC1a blocker, PcTx1, injected in ACC. CFA-induced inflammatory pain was then behaviorally assessed. B, Example Nissl-stained image depicting the location of the injection cannula (indicated by the asterisk). Scale bar, 500 μm. C, PcTx1 pretreatment prevented CFA-evoked thermal hyperalgesia. n = 10 mice for each group. D, Schematics of the experimental protocol for E. E, PcTx1 did not affect normal heat nociception (n = 8 mice per group). F, Schematics of the experimental protocol for G–I. G–I, Open field test showing no difference between saline- and PcTx1-treated groups in the time spent in the center zone (G), distance traveled in the center arena (H), or total distance traveled (I) (saline group, n = 8 mice; PcTx1 group, n = 9 mice). Data are mean ± SEM. **p < 0.01, ***p < 0.001, N.S., not significant.