Figure 2.

The tns-1 gene encodes a homolog of Tensin. A, SVH-1–SVH-2 pathway required for axon regeneration in C. elegans. Activation of SVH-2 receptor tyrosine kinase by SVH-1 growth factor activates the JNK pathway. The EMB-9 collagen–DDR-2 pathway modulates the SVH-1–SVH-2 pathway. B, Structures of the tns-1 and tns-1s genes. Boxes indicate exons and lines indicate introns and promoters. The regions deleted in the ok80 and ok581 alleles are indicated by black bars. C, Structure of TNS-1 protein. Schematic diagrams of TNS-1, a short form of TNS-1 (TNS-1S) and human Tensin-3 are shown. The domains shown are the NH₂-terminal (blue), SH2 (yellow), and PTB (red) domains. The regions deleted by the ok80 and ok581 alleles are indicated by black bars. Identity (%) in each domain is shown.