Table 3.
Prevalence of latent tuberculosis infection and active tuberculosis disease among diabetic compared to non-diabetic adultsa
| LTBI (n = 1113) | TB (n = 2032) | |||||
|---|---|---|---|---|---|---|
| n (%) | PR (95% CI) | aPR (95% CI)b | n (%) | PR (95% CI) | aPR (95% CI)b | |
| No history of diabetes | 561/1044 (53.7) | 1.00 (Referent) | 1.00 (Referent) | 623/1667 (37.4) | 1.00 (Referent) | 1.00 (Referent) |
| Prior diabetes diagnosis | 44/69 (63.8) | 1.24 (1.04, 1.48) | 1.20 (0.99, 1.45) | 296/365 (81.1) | 3.83 (2.01, 7.30) | 2.13 (1.95, 2.33) |
| Sensitivity analyses | ||||||
| RBG < 200 | 553/1019 (54.2) | 1.00 (Referent) | 1.00 (Referent) | 576/1595 (36.1) | 1.00 (Referent) | 1.00 (Referent) |
| RBG ≥ 200 or prior diabetes diagnosis | 52/94 (55.3) | 1.04 (0.86, 1.25) | 1.00 (0.82, 1.21) | 343/437 (78.5) | 2.17 (1.90, 2.48) | 2.06 (1.90, 2.23) |
| RBG < 140 | 517/928 (55.7) | 1.00 (Referent) | 1.00 (Referent) | 440/1368 (32.2) | 1.00 (Referent) | 1.00 (Referent) |
| RBG ≥ 200 or prior diabetes diagnosis | 52/94 (55.3) | 1.01 (0.84, 1.22) | 0.97 (0.80, 1.18) | 343/437 (78.5) | 2.47 (2.25, 2.71) | 2.19 (2.00, 2.39) |
aPR adjusted prevalence ratio, CI confidence interval, LTBI latent tuberculosis infection, PR prevalence ratio, RBG random blood glucose (mg/dL), TB tuberculosis
a All models account for clustering at the family-level with an exchangeable correlation matrix. For LTBI, the referent group is LTBI-negative household contacts. For TB, the reference group is all household contacts
b Adjusted for age, sex, body mass index category, smoking, and hazardous alcohol use