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Two previous hypotheses for the evolution of canonical MHC class I region. Hypothesis I (Kumánovics et al., 2003) postulated that all of the three MHCI duplication blocks were present in the common ancestor of mammals, and were lost in taxon‐specific fashion, whereas hypothesis II (Ng et al., 2016) proposed that these duplication blocks arose in a stepwise manner, with the β duplication block originating first and the α block last
