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. 2019 Aug;370(2):206–217. doi: 10.1124/jpet.119.258954

Fig. 5.

Fig. 5.

Effects of Dusp5 KO on glomerular injury. (A) Comparison of glomerular injury in the renal cortex of normotensive and hypertensive WT and Dusp5 KO rats. (B) Representative pictures of nephrin immunostaining in glomeruli of normotensive and hypertensive Dusp5 KO and WT rats. (C) Comparison of Palb in isolated glomeruli. The decline in fluorescence intensity was greater in the glomeruli of DOCA-salt–treated Dusp5 KO and WT rats, indicating an increased reflection coefficient (σ). N = 4–6 rats per group. Numbers in the parentheses indicate the numbers of rat and glomeruli studied. Mean values ± S.E.M. are presented. *P < 0.05 from the corresponding value in Dusp5 KO vs. WT rats. #P < 0.05 from DOCA-salt treated vs. baseline value within strain.