TABLE 3.
Inner diameters of isolated perfused interlobular artery in response to selective ERK1/2 inhibitor FR180204 and PKC inhibitor BIM III
Absolute values of inner diameter of isolated perfused IA and AA in the presence of a selective ERK1/2 inhibitor FR180204 (1 μM) and PKC inhibitor BIM III. Mean values ± S.E.M. are presented.
| IA |
Rats |
Perfusion Pressure |
||
|---|---|---|---|---|
| 60 mm Hg |
120 mm Hg |
180 mm Hg |
||
| ID (μm) | ||||
| FR180204 (1 μM) | WT | 28.8 ± 3.5 | 28.2 ± 3.7 | 28.8 ± 3.8 |
| WT FRa | 41.0 ± 6.0 | 45.1 ± 6.2 | 47.4 ± 6.1 | |
| Dusp5 KOb | 24.3 ± 1.9 | 23.1 ± 2.3 | 21.2 ± 1.6 | |
| Dusp5 KO FRa,b | 36.2 ± 3.2 | 44.0 ± 3.0 | 49.8 ± 3.1 | |
| BIM III (300 nM) | WT | 28.8 ± 3.5 | 28.2 ± 3.7 | 28.8 ± 3.8 |
| WT BIMa | 26.3 ± 3.6 | 29.0 ± 4.0 | 31.8 ± 4.6 | |
| Dusp5 KOb | 24.3 ± 1.9 | 23.1 ± 2.3 | 21.2 ± 1.6 | |
| Dusp5 KO FRa,b | 30.3 ± 2.7 | 35.3 ± 3.1 | 38.4 ± 3.3 | |
FR, FR180204.
a
Indicates P < 0.05 from the changes in diameter in response to drug treatments within strain.
b
Indicates P < 0.05 from the corresponding value in Dusp5 KO vs. WT rats.