Figure 2. .

Serial elastographic analyses before treatment (a) and after first (b), second (c) and third (d) cycle of NACT in a locally advanced tumor showing clustered pleomorphic microcalcifications. Mild increase in strain ratio is seen after three cycles of chemotherapy (strain ratio 7.9) as compared to the baseline values (strain 6.9). No decrease in strain ratio is seen at any point during the course of chemotherapy. Peritumoral area appears hard (red) suggestive of tumor desmoplasia (black arrows) with mild increase in peritumoral stiffness (*). NACT, neo-adjuvant chemotherapy.