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. 2019 Jun 9;10(16):3842–3850. doi: 10.7150/jca.33989

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Fig 4 — IKAROS suppresses RAG1 expression. (A) The promoter activity of RAG1 promoters measured by luciferase reporter assay following transfection with IKAROS or control vector in HEK293 cells. (B) Effect of expression of IKAROS in Nalm6 cells. The cells were transduced with a vector containing IKAROS as compared to the control vector. (C) qPCR of RAG1 and IKZF1 expression in the Nalm6 cells following IKZF1 shRNA treatment as compared to scramble shRNA cells. Gene expression is evaluated by RT-qPCR using total RNA isolated from the cells transfected with scramble shRNA (siControl) or IKZF1shRNA (siIKZF1) for 2 days.