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. 2019 Jun 9;10(16):3757–3766. doi: 10.7150/jca.31660

Table 2.

The association of demographics and clinicopathologic characteristics with different serum tumor markers (# means the p values compared T3 with T4)

Variables CEA CA125 CA19-9 CA242
Positive Negative p-value Positive Negative p-value Positive Negative p-value Positive Negative p-value
(N=316) (N=419) (N=236) (N=499) (N=166) (N=569) (N=151) (N=584)
Gender 0.380 0.973 0.301 0.234
Male 186 260 143 303 95 351 98 348
Female 130 159 93 196 71 218 53 236
Age 0.478 0.127 0.377 0.132
<65 138 194 97 235 70 262 60 272
≥65 178 225 139 264 96 307 91 312
Clinical stage 0.000 0.177 0.000 0.003
II 159 269 129 299 76 352 72 356
III 157 150 107 200 90 217 79 228
T stage 0.012 0.095 0.250 0.305
T1+T2 6 13 7 12 2 17 2 17
T3 55 108 0.005# 41 122 0.033# 33 130 0.358# 29 134 0.280#
T4 255 298 188 365 131 422 120 433
N stage 0.001 0.151 0.000 0.003
N0 159 269 129 299 76 352 72 356
N1 92 84 67 109 45 131 39 137
N2 65 66 40 91 45 86 40 91
Location 0.006 0.011 0.319 0.008
Right colon 84 151 90 145 55 180 63 172
Left colon 114 112 75 151 57 169 45 181
Rectum 156 118 71 203 54 220 43 231
Pathology type 0.056 0.018 0.041 0.000
Adenocarcinoma 290 399 214 475 150 539 129 560
Other 26 20 22 24 16 30 22 24
Differentiation 0.447 0.453 0.044 0.004
Moderate and well 182 253 135 300 87 348 74 361
Poor 134 166 101 199 79 221 77 223
Lymphatic invasion 0.014 0.006 0.004 0.068
Yes 205 234 158 281 115 324 100 339
No 111 185 78 218 51 245 51 245
Vascular invasion 0.123 0.864 0.000 0.001
Yes 51 51 32 70 37 65 33 69
No 265 368 204 429 129 504 118 515
Perineural invasion 0.157 0.930 0.430 0.438
Yes 11 24 11 24 6 29 9 26
No 305 395 225 475 160 540 142 558
Metastasis & recurrence 0.001 0.094 0.000 0.000
Yes 116 106 81 141 71 151 71 151
No 200 313 155 358 95 418 80 433
Survival status 0.000 0.000 0.000 0.000
Alive 193 307 131 369 90 410 67 433
Dead 123 112 105 130 76 159 84 151