Table 3.
Univariate and multivariate Cox regression analysis for DFS and OS
| Variables | DFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Univariate analysis | ||||
| Gender (male vs. female) | 1.060 (0.809- 1.390) | 0.672 | 1.082 (0.831- 1.407) | 0.559 |
| Age (<65 vs. ≥65 ) | 0.842 (0.647- 1.095) | 0.199 | 1.104 (0.852- 1.429) | 0.454 |
| Clinical stage (II vs. III) | 2.242 (1.718- 2.926) | 0.000 | 2.412 (1.859- 3.131) | 0.000 |
| T stage | ||||
| T1+T2 | 1 (Referent) | 1 (Referent) | ||
| T3 | 0.599 (0.267- 1.347) | 0.215 | 0.836 (0.354- 1.976) | 0.684 |
| T4 | 1.013 (0.476- 2.156) | 0.973 | 1.404 (0.623- 3.167) | 0.413 |
| N stage | ||||
| N0 | 1 (Referent) | 1 (Referent) | ||
| N1 | 1.611 (1.160- 2.237) | 0.004 | 1.754 (1.276- 2.411) | 0.001 |
| N2 | 3.308 (2.426- 4.510) | 0.000 | 3.513 (2.597- 4.752) | 0.000 |
| Location | ||||
| Right colon | 1 (Referent) | 1 (Referent) | ||
| Left colon | 1.233 (0.880- 1.730) | 0.224 | 1.072 (0.775- 1.483) | 0.675 |
| Rectum | 1.218 (0.881- 1.684) | 0.234 | 1.086 (0.796- 1.482) | 0.603 |
| Pathology type (Adenocarcinoma vs. other) | 0.443 (0.292- 0.672) | 0.000 | 0.484 (0.322- 0.727) | 0.000 |
| Differentiation (Moderate and well vs. poor) | 1.475 (1.133- 1.919) | 0.004 | 1.547 (1.196- 1.999) | 0.001 |
| Lymphatic invasion (yes vs. no) | 1.362 (1.032- 1.797) | 0.029 | 1.383 (1.051- 1.819) | 0.020 |
| Vascular invasion (yes vs. no) | 1.998 (1.444- 2.765) | 0.000 | 1.878 (1.371- 2.573) | 0.000 |
| Perineural invasion (yes vs. no) | 1.557 (0.769- 3.155) | 0.219 | 2.162 (0.961- 4.864) | 0.062 |
| CEA (positive vs. negative) | 1.665 (1.279- 2.167) | 0.000 | 1.661 (1.286- 2.146) | 0.000 |
| CA125 (positive vs. negative) | 1.373 (1.045- 1.805) | 0.023 | 1.904 (1.472- 2.463) | 0.000 |
| CA19-9 (positive vs. negative) | 1.851 (1.396- 2.455) | 0.000 | 1.863 (1.417- 2.450) | 0.000 |
| CA242 (positive vs. negative) | 2.343 (1.765- 3.109) | 0.000 | 2.787 (2.132- 3.643) | 0.000 |
| Multivariate analysis | ||||
| N stage | ||||
| N0 | 1 (Referent) | 1 (Referent) | ||
| N1 | 1.854 (1.264- 2.719) | 0.002 | 1.997 (1.386- 2.876) | 0.000 |
| N2 | 3.653 (2.442- 5.465) | 0.000 | 4.298 (2.919- 6.328) | 0.000 |
| Pathology type (Adenocarcinoma vs. other) | 0.569 (0.362- 0.894) | 0.014 | 0.625 (0.403- 0.970) | 0.036 |
| Differentiation (M and W vs. poor) | 1.276 (0.958- 1.699) | 0.096 | 1.309 (0.989- 1.733) | 0.060 |
| Lymphatic invasion (yes vs. no) | 1.656 (1.139- 2.407) | 0.008 | 1.802 (1.254- 2.588) | 0.001 |
| Vascular invasion (yes vs. no) | 1.522 (1.086- 2.134) | 0.015 | 1.440 (1.038- 1.999) | 0.029 |
| CEA (positive vs. negative) | 1.282 (0.967- 1.700) | 0.084 | 1.238 (0.942- 1.627) | 0.125 |
| CA125 (positive vs. negative) | 1.303 (0.983- 1.726) | 0.066 | 1.846 (1.416- 2.406) | 0.000 |
| CA19-9 (positive vs. negative) | 1.156 (0.830- 1.609) | 0.391 | 1.113 (0.810- 1.529) | 0.510 |
| CA242 (positive vs. negative) | 1.641 (1.178- 2.286) | 0.003 | 2.003 (1.471- 2.728) | 0.000 |