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. 2019 Jun 9;10(16):3778–3788. doi: 10.7150/jca.30359

Figure 6.

Figure 6

THZ1 inhibited the Notch signaling pathway. (A) RT-PCR was conducted to detect the mRNA expression of Notch1, Notch2, Notch3, MAML1, RBJ and Hes1 in LECs after co-treated LECs with TGFβ2 (10ng/ml) and THZ1 (0, 50, 100, 200,400nM) or DMSO for 24 hour, (B) Protein level of Notch1, Notch2 was detected by western blot with GAPDH as the internal control. Quantification of protein level from three independent experiments are showed in C. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 vs. Control.