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. 2019 Jul 12;14:5187–5199. doi: 10.2147/IJN.S205350

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© 2019 Spadari et al.

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Fungal burden and histopathological analysis of Galleria mellonella larval tissue infected with yeasts and treated or not with free miltefosine (MFS) and miltefosine-loaded alginate nanoparticles (MFS.Alg). Fungal burden data is represented by the mean ± standard deviation. *P<0.05 and **P<0.01 when compared with the untreated group (one-way ANOVA with Dunnet’s post-test). Fungal burden, filamentation and dissemination of yeasts in Galleria mellonella larvae were analyzed by visualization of larval tissue histological sections of larvae untreated, treated with MFS (40 mg/kg), or treated with MFS.Alg (200 mg/kg). Black arrows indicate yeasts and white arrows indicate C. albicans filamentation. Bars: 50 μm.