Table 2.
Susceptibility of Candida spp. and Cryptococcus spp. strains to fluconazole (FLC), amphotericin B (AMB), free miltefosine (MFS) and miltefosine-loaded alginate nanoparticles (MFS.Alg)
| Strains | Concentrations (µg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
| FLCa | AMBa | MFS | MFS.Alg | |||||
| MIC | MFC | MIC | MFC | MIC | MFC | MIC | MFC | |
|
C. albicans SC5314 |
2 | 4 | 0.12 | 0.12 | 1 | 1 | 300 | 600 |
|
C. albicans IAL-40 |
64R | >64 | 0.12 | 0.12 | 1 | 1 | 600 | >600 |
|
C. glabrata ATCC 2001 |
16R | >64 | 0.12 | 0.25 | 0.5 | 0.5 | 150 | >600 |
|
C. glabrata IAL-23 |
8SDD | >64 | 0.12 | 0.25 | 0.5 | 1 | 37.5 | >600 |
|
C. krusei ATCC 6258 |
64R | >64 | 0.5 | 0.5 | 2 | 4 | 600 | >600 |
|
C. krusei IAL-30 |
64R | >64 | 0.25 | 0.5 | 1 | 1 | 600 | >600 |
|
C. parapsilosis ATCC 22019 |
2 | 4 | 0.12 | 0.25 | 1 | 1 | 600 | >600 |
|
C. parapsilosis IAL-17 |
>64R | >64 | 0.25 | 0.25 | 2 | 2 | 600 | >600 |
|
C. tropicalis ATCC 200956 |
>64R | >64 | 2R | 2 | 1 | 2 | 600 | >600 |
|
C. tropicalis IAL-01 |
2 | 16 | 0.25 | 0.25 | 2 | 2 | 300 | >600 |
|
C. neoformans CAP59 |
1 | 32 | 0.03 | 0.03 | 1 | 1 | 1.56 | 1.56 |
|
C. neoformans H99 |
4 | 4 | 0.25 | 0.25 | 2 | 2 | 25 | 400 |
|
C. gattii ATCC 56990 |
2 | 32 | 0.25 | 0.25 | 0.5 | 0.5 | 12.5 | 25 |
Note: aThe assay was repeated and the results obtained here corroborated with previously published data.66
Abbreviations: MIC, minimum inhibitory concentration; MFC, minimum fungicidal concentration; R, resistant; SDD, susceptibility dose-dependent.