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. Author manuscript; available in PMC: 2019 Jul 17.
Published in final edited form as: J Neurosci Res. 2016 Jul 20;95(5):1174–1181. doi: 10.1002/jnr.23799

Fig. 3.

Fig. 3.

Effect of fingolimod treatment on PFC presynaptic calcium concentration as measured by fluorescent calcium indicators. Baseline levels of intracellular calcium did not significantly differ between genotype, as measured by fluo-4 and fluo-3 (WT SAL, n = 9; MUT SAL, n = 6). After treatment, fluo-4 measures showed significant increases in intracellular calcium in both WT (n = 9; ★★P = 0.001) and dysbindin-1 MUT (n = 6; ★★★P < 0.0001) mice. Both dyes indicate a near doubling of intracellular calcium for both genotypes after treatment with fingolimod. SAL, saline.