Table 1.
Loss of STC2 sensitizes CNE2 cells
| Group | D0(Gy) | Dq(Gy) | N | SF2 | SERD0 | |
|---|---|---|---|---|---|---|
| Normoxia | CNE2 | 0.920 | 4.079 | 4.434 | 0.414 | |
| CNE2-STC2-KOA | 0.835 | 2.742 | 3.282 | 0.270 | 1.10 | |
| CNE2-STC2-KOB | 0.826 | 2.398 | 2.905 | 0.236 | 1.11 | |
| Hypoxia | CNE2 | 1.683 | 3.411 | 2.027 | 0.458 | |
| CNE2-STC2-KOA | 1.268 | 2.492 | 2.012 | 0.240 | 1.33 | |
| CNE2-STC2-KOB | 1.184 | 2.275 | 1.921 | 0.215 | 1.42 |
Notes: Radiosensitivity of cell lines was analyzed using the standard multitarget, single-hit model. Sensitivity enhancing ratio (SERD0) is defined by D0 of control CNE2 vs D0 of the testing cell lines cultured under identical conditions.
Abbreviations: D0, mean lethal dose; Dq, quasi-threshold dose; N, extrapolation number; SF2, survival fraction of 2 Gy.