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. Author manuscript; available in PMC: 2019 Jul 17.
Published in final edited form as: Gene. 2015 Sep 8;573(2):177–187. doi: 10.1016/j.gene.2015.08.062

Figure 4. Reduced function of INa as a consequence of loss-of-function mutation in SCN5A.

Figure 4.

A) Decreased peak INa lowers the upstroke velocity of the action potential (red trace). B) Shifts in voltage dependence of (in)activation (dashed lines) that result in loss-of-function of INa. Apart from mutations that lower the amount of channels at the membrane or reduce conductivity of the channel, this phenomenon forms an alternative mechanism for reduced functionality.