Table 3: SCN5A genetic variation in the general population.

Frequencies of different types of variants with a minor allele frequency of <1% in the general population as can be found in the databases of Exome Variant Server (EVS) (http://evs.gs.washington.edu/EVS/) and Exome Aggregation Consortium (ExAC) (http://exac.broadinstitute.org/)

Type of mutation	frequency in EVS (n>6500)	Frequency in ExAC (n>120,000)
Missense	1.89%	7.40%
Splice	0.02%	0.01%
Stopgain	-	0.01%
Frameshift	-	0.01%
In frame deletion	-	0.02%
Total	1.91%	7.45%