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. 2015 Nov 25;146(2):236–242. doi: 10.3945/jn.115.216580

FIGURE 4.

FIGURE 4

Apc inactivation leads to constitutive repression of Shp and Ibabp and activation of Cox-2 expression in adjacent colonic mucosa and colon tumors of ApcMin/+ mice. Bars represent qRT-PCR quantitation (fold of C57BL/6J) for (A) Shp, (B) Ibabp, and (C) Cox-2 corrected for Gapdh as an internal control in NT colonic mucosa and colon tumors from ApcMin/+ and ApcMin/+ Fxr−/− mice. Values are means ± SEMs, n = 4 (mean of 6 replicates/mouse). Means without a common letter differ, P < 0.05. Apc, adenomatous polyposis coli; Cox-2, cyclooxygenase-2; Fxr, farnesoid X receptor; Ibabp, ileal bile acid-binding protein; NT, nontumor; Shp, small heterodimer partner.