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Schematic model of the E2 intracellular activated pathway impacting on NGB expression levels/intracellular localization and the related antiapoptotic role of both mitochondrial NGB and AKT which appears to be double linked with NGB function. E2: 17β-estradiol; ERα: estrogen receptor α; PI3K: phosphatidylinositol 3 kinase, Cyt-c: cytochrome c. For further detail, see the text.
